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Moderate drinking can reduce the risk
of death from cardiovascular disease.
Lancet, 355 (9198):123, 2000. (152787) Previous studies have shown that
light to moderate drinking can reduce the risk of death from
cardiovascular disease. However, heavy drinking is associated with
increased mortality from liver disease, cancers of the oropharynx and
esophagus, and non-coronary cardiovascular disease. Because of these
mixed effects, Michael Gaziano and colleagues set out to define the
range of drinking within which the benefits of alcohol consumption
outweigh the risks. In 1983, they collected data on alcohol intake from
89,299 male physicians aged 40-84 years.
There were 3,216 deaths during the mean follow-up
period of 5.46 years. Compared with men who never drank, those who
consumed one, two to four, or five to six drinks a week, or one a day,
had significantly lower risk of death from all causes (multivariate
relative risks of 0.74, 0.77, 0.78, and 0.82 respectively). Men who
drank two or more drinks per day seemed to have about the same overall
risk of dying as those who never drank.
According to Richard Peto, however, the effects seen
with such small quantities are unusual. He notes that studies of British
doctors suggest that the lowest death rates in middle and old age are
associated with about three drinks a day, not three a week. This
possible underestimation of the protective range may stem from U.S.
physicians' underreporting of their alcohol consumption. Peto finds it
peculiar that only 3 percent of the physicals in the study by Gaziano et
al. reported consuming more than one drink a day.
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